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Glyburide-Metformin

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 (2-5 business days)
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More about Glyburide-Metformin

This combination medication is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications. This product contains 2 medications. Glyburide belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin and by decreasing the amount of sugar that your liver makes. Metformin works by decreasing the amount of sugar that your liver makes and that your stomach/intestines absorb. Both of these medications work by helping to restore your body's proper response to the insulin you naturally produce. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with meals as directed by your doctor, usually once or twice a day. Drink plenty of fluids while taking this medication unless otherwise directed by your doctor. The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects (such as upset stomach and low blood sugar), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Your doctor will adjust your dose based on your blood sugar to find the best dose for you. Follow your doctor's instructions carefully. If you are already taking another diabetes drug (such as chlorpropamide), follow your doctor's directions carefully for stopping the old drug and starting this combination medication. If you are also taking colesevelam, take glyburide/metformin at least 4 hours before colesevelam. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It may take up to 2 weeks before you get the full benefit of this drug. Tell your doctor if your condition does not improve or if it worsens (your blood sugar is too high or too low).
See also Warning section. Nausea, stomach upset, diarrhea, or weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If stomach symptoms return later (after you are on the same dose for several days or weeks), tell your doctor right away. Stomach symptoms that occur after the first days of your treatment may be a sign of lactic acidosis. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, signs of infection (such as persistent sore throat, fever), persistent nausea, severe stomach/abdominal pain, yellowing eyes/skin, dark urine. This medication can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
See also How To Use section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: bosentan. Many drugs can affect your blood sugar, making it harder to control. Before you start, stop, or change any medication, talk with your doctor or pharmacist about how the medication may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high or low blood sugar. (See also Side Effects section.) Your doctor may need to adjust your diabetes medication, exercise program, or diet. Beta-blocker medications (including metoprolol, propranolol, glaucoma eye drops such as timolol) may prevent the fast/pounding heartbeat you would usually feel when your blood sugar falls too low (hypoglycemia). Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs. Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients that could affect your blood sugar. Ask your pharmacist about using those products safely.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: rapid breathing, severe drowsiness, slow/irregular heartbeat.
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 (2-5 business days)
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Frequently Asked Questions

We've compiled a list of commonly asked questions for your convenience. If you are unable to find the answer to your question, please contact us for further assistance. It's just one more way UPRx prioritizes your self-care.


If you are one of half of the US population who benefits from taking prescription drugs, then UPRx is for you. We offer cash medication so you can…

• Bypass high insurance copays.
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• Have access to lower priced medications
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• Avoid the hassle of going to the pharmacy to fill your prescriptions.

If any of the above sound as awesome to you as they do to us, we can safely say that UPRx is the alternative for you.
In order to fulfill your order we will need a corresponding prescription. However, if you don’t already have one we can help you with that! We have partnered with a third-party Telehealth company, providing online consultations with US licensed doctors, for a $5 fee.
We make it easy! All we require is contact information for your pharmacy or doctor’s office, and we will take care of transferring your prescription over for you. If you do not have an existing prescription, you can talk to one of our online physicians now and they can submit a prescription directly into our system for you.
UPRx.com offers both generic and brand-name prescription medications. The generic versions are generally significantly cheaper than the brand name version of a drug. However, please consult with your doctor to find out which variation of any specific drug is best for you.
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After your order is placed, UPRx will retrieve your valid prescription from your doctor or pharmacy. Once the prescription is confirmed as authorized and corresponding to your order, our participating pharmacy begins to process your order. Depending on the specific drug and location, we can ship out some products as soon as same day, and we commit to shipping out all products within 48 hours of verifying your prescription.
Our site does not support insurance at this time, as we are focusing our efforts on getting you the best cash price. You may not know this, but there are some instances where it’s significantly cheaper to pay cash for a medication rather than to order it through your insurer’s pharmacy benefits program. Here at UPRx, we cut out the middleman and do the negotiating for you- providing you with the same drugs, for less pay.
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When UPRx obtains your medical information while acting on your behalf, we will maintain the privacy and security of that information in accordance with the standards of the HIPAA security regulations. Additionally, UPRx is fully registered and operates in multiple locations across the United States of America. Our partner pharmacy, Apogee BioPharm, is licensed and operated in all 50 states and territories. At UPRx we are committed to only purchasing locally sourced items and products.

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